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Last updateWed, 26 Jul 2017 7pm

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How to Choose the Best Rapid Prototyping Method

How to Choose the Best Rapid Prototyping Method

As new products are designed, including ...

Monitoring Valve Health via the Internet

Monitoring Valve Health via the Internet

Most valve end users are already using s...

Valves in Oxygen Service

Valves in Oxygen Service

In his presentation at VMA’s 2017 ...

Thermal Spray Coating

Thermal Spray Coating

Q: What are the pros and cons of us...

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Industry Headlines

TAQA Awards Schlumberger EPCIC Contract for Otter Field

Wednesday, 26 July 2017  |  Chris Guy

OneSubsea, a Schlumberger company, has been awarded an engineering, procurement, construction, installation and commissioning (EPCIC) contract for a s...

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The Actuation Selection Process

The Actuation Selection Process

Tuesday, 25 July 2017  |  Carlos Gamero

A common misconception in our industry is that actuating a valve is as simple as putting the most cost-efficient actuator on top of your valve of choi...

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Industry Headlines

TAQA Awards Schlumberger EPCIC Contract for Otter Field

29 MINS AGO

OneSubsea, a Schlumberger company, has been awarded an engineering, procurement, construction, installation and commissioning (EPCIC) contract for a subsea multiphase boosting system by TAQA for the Otter field in the UK North Sea. OneSubsea leverages Cameron flow control, process technologies and m...

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Crane Co. Reports Second Quarter Results

23 HOURS AGO

Crane Co. reported second quarter 2017 earnings of $1.14 per diluted share, compared to $1.15 per share in the second quarter of 2016. Excluding Special Items, second quarter 2017 earnings per diluted share were $1.17, compared to $1.21 per share in the second quarter of 2016.

Second quarter 2017 sale...

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Shale Sector to Be Cash Flow Positive by 2020

57 MINS AGO

The tight oil sector has struggled to generate positive cash flow since 2010. Last year, only one company in the sector posted positive cash flow. But there is light at the end of the tunnel. Wood Mackenzie’s new report " When will tight oil make money? " calculates that the five largest tight oil...

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U.S. Chemical Production Moved Higher in June

1 DAY AGO

According to the American Chemistry Council (ACC), the U.S. Chemical Production Regional Index (U.S. CPRI) edged higher by 0.3% in June, following a 0.3% gain in May, and a 0.4% decline in April, as measured on a three-month moving average (3MMA) basis. During June, output grew in all regions except t...

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U.S. Consumer Confidence Rebounds in July

6 HOURS AGO

The Conference Board Consumer Confidence Index, which had declined marginally in June (a downward revision), improved in July . The Index now stands at 121.1, up from 117.3 in June. The Present Situation Index increased from 143.9 to 147.8, while the Expectations Index rose from 99.6 last month to 103...

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IHS Market PMI Index Reached Four-Month High in July

1 DAY AGO

July data revealed a further acceleration in business activity growth across the U.S. private sector. At 54.2, up from 53.9 in June, the seasonally adjusted IHS Markit Flash U.S. Composite PMI Output Index signaled the strongest rate of expansion since January.

The pickup in business activity growth ...

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The Biopharm Industry

vmwnt12_biopharm_cvr

This segment of the chemical processing industry must deal with levels of cleanability and sterility that will ensure the safety of those who use or make the products.

As the world’s populations grow and age, developing countries expectations rise and new research brings new health solutions to the world, the biopharmaceutical (biopharm) industry flourishes. Like all chemical processing, biopharm has its own set of standards, special processing needs and challenges in materials and design.


THE CHEMICAL INDUSTRY

At its most general level, one can define the chemical industry as the aggregate of entities engaged in processing raw materials using chemical reactions (often aided by pressure and/or forms of energy such as heat) to convert those materials into products. That general level has numerous subgroups, such as biopharmaceutical, organic/inorganic chemicals, industrial gases, petrochemicals, agrochemicals, polymers and paints. These subgroups are categorized further by the end-product goods and commodities such as dyes, acids, alcohols, fertilizers, hydrogen, nitrogen, herbicides, ammonia, soaps, detergents, hair sprays, enamels, varnishes and many more.

Commonly, the processes required to manufacture these products use constituents or conversion enablers that are toxic, or they result in products and byproducts that may be toxic themselves. The inputs and outputs to those processes can present additional challenges because of physical and chemical properties that can make media extremely corrosive or abrasive. Also, the media can be difficult to propagate and control throughout the process flow in situations where physical/chemical properties result in media that is semi-solid.

In each segment of the industry and in every subcategory of these segments, valves play a critical role. A variety of valves are appropriate for various applications and deployed for handling different types of media. Covering the entire industry is too great a task for one article. Therefore, the information that follows highlights where and how valves are used in chemical processing for the biopharm market.


THE MARKET

The biopharm industry can be divided into two segments: Pharmaceutical, which uses chemical processes to manufacture therapeutic and health-related products; and biotechnology (biotech), which uses living organisms and biological processes to create products used in many fields such as pharmacology, medicine, agriculture and many others. A primary example is therapeutic protein used for medical and therapeutic applications. Most biotech applications involve cell cultures of genetically modified organisms including yeasts, insect cells, bacteria cells or mammalian cells.

A full range of pumps, valves and instrumentation comparable to other processing systems can be used in the biopharm industry. However, stringent requirements regarding cleanability and materials of construction mean that some products that perform ordinary and useful flow control functions in other applications must either be used with great caution or not used at all. An example is check valves. Check valves are installed tentatively because even sanitary check valves allow formation of “dead areas,” despite the fact they are functioning according to specifications. Such areas potentially harbor contaminants or toxic agents.

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